140 mg/kg body weight, orally, once as a loading dose.įor children there is a diluent added to the NAC so that there is no electrolyte and volume complications. May see a dose-dependent increase in PT following NAC in patients without hepatotoxicity. Give NAC until LFTs improve (not until APAP level is 0) Almost 100% effective if given 24 hr post-ingestion, even with fulminant hepatic failure.Third dose: 100mg/kg in 500 mL D5W over 16hr.Second (maintenance) dose: 50mg/kg in 250 mL D5W over 4hr.Loading dose: 150mg/kg in 100 mL D5W over 60min.70 mg/kg PO q4hr x17 doses additional dilute to 5% soln.Less preferred than IV route due to unpleasant taste and smell.See above guidelines for when to dose NAC PO If angioedema develops NAC infusion should be stopped and restarted an hour after symptom resolution.
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